The mitogen-activated protein kinase kinase kinase kinases(MAP4Ks)signaling pathway plays a pivotal role in axonal regrowth and neuronal degeneration following insults.Whether targeting this pathway is beneficial to brain injury remains unclear.In this study,we showed that adeno-associated virus-delivery of the Citron homology domain of MAP4Ks effectively reduces traumatic brain injury-induced reactive gliosis,tauopathy,lesion size,and behavioral deficits.Pharmacological inhibition of MAP4Ks replicated the ameliorative effects observed with expression of the Citron homology domain.Mechanistically,the Citron homology domain acted as a dominant-negative mutant,impeding MAP4K-mediated phosphorylation of the dishevelled proteins and thereby controlling the Wnt/β-catenin pathway.These findings implicate a therapeutic potential of targeting MAP4Ks to alleviate the detrimental effects of traumatic brain injury.
To improve the accuracy of short text matching,a short text matching method with knowledge and structure enhancement for BERT(KS-BERT)was proposed in this study.This method first introduced external knowledge to the input text,and then sent the expanded text to both the context encoder BERT and the structure encoder GAT to capture the contextual relationship features and structural features of the input text.Finally,the match was determined based on the fusion result of the two features.Experiment results based on the public datasets BQ_corpus and LCQMC showed that KS-BERT outperforms advanced models such as ERNIE 2.0.This Study showed that knowledge enhancement and structure enhancement are two effective ways to improve BERT in short text matching.In BQ_corpus,ACC was improved by 0.2%and 0.3%,respectively,while in LCQMC,ACC was improved by 0.4%and 0.9%,respectively.
