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治疗铜中毒的新型高效络合剂对叔丁基硫杂杯[4]芳烃被引量：4: 2012年; 以超分子化学基本原理为指导,系统研究了对叔丁基硫杂杯[4]芳烃(简称TCA)作为受体对Cu2+(底物)的分子识别作用.结果表明,TCA对Cu2+具有优异的识别能力,且识别能力不受大量K+,Na+和Ca2+等共存离子的影响.TCA对Cu2+的识别作用优于驱铜药物2,3-二巯基丁二酸(DMSA).TCA对Cu2+的作用受竞争配体氨基酸的影响,在血铜含量超标时,人体正常浓度的氨基酸对TCA与Cu2+作用的影响很小;而当Cu2+浓度降到正常血铜值时,体内氨基酸的存在可使TCA的排铜效率降低,避免发生铜的过多流失.TCA对Cu2+的作用优于对Zn2+的作用,但共存离子Zn2+与Cu2+产生协同作用,使TCA对Cu2+和Zn2+的萃取率均增加.可通过降低萃取剂的浓度来减弱TCA与Zn2+的结合,达到驱铜保锌的最佳效果.TCA有望发展为取代DMSA的更有效的驱铜药物.; 顾金英朱明莉施宪法; 关键词：芳烃铜离子分子识别

大环配合物在核酸切割中的应用被引量：4: 2008年; 核酸切割试剂的研究是化学和分子生物学中最为活跃的前沿领域之一。研究核酸切割试剂,不仅是因为对核酸酶催化机理进行深入了解之需,同时还因为人工核酸酶在基因治疗中有着诱人的前景。大环配合物的合成、结构及其对核酸的切割作用已有广泛的文献报道。本文综述了作为重要的核酸切割试剂的大环多胺配合物和氮杂冠醚配合物对核酸的切割作用及其规律性,并展望了今后的发展与应用方向。; 李凤莲石硕姚天明; 关键词：大环配合物多胺氮杂冠醚

Role of Individual Repeat in Tau Microtubule Binding Domain in In Vitro Aggregation. A Convenient Method for Monitoring Tau Polymerization: ＜正＞Microtubule-associated protein tau is a highly soluble protein under physiological conditions. In the brain...; Yao Tian-Ming; 文献传递

Inhibition of Tau Aggregation by flavonoids and tannic acid: Inhibition of anomalous aggregation of tau protein Would be an attractive therapeutic target for Alzheimer''''...; Shuo ShiTianming Yao; 关键词：INHIBITOR TAU PROTEIN

含腺嘌呤的杯芳烃衍生物的合成、表征及其对核苷碱基的分子识别性质被引量：5: 2008年; 设计合成了一种新型含腺嘌呤基的杯[4]芳烃衍生物(AC)——5,11,17,23-四叔丁基-25,27-二羟基-26-[1-(9-腺嘌呤)-丙氧基]-28-溴丙氧基杯[4]芳烃,通过红外光谱、元素分析、核磁共振谱和电喷雾质谱等手段对其进行了表征,确认为目标产物;并采用紫外分光光度法研究了AC的分子识别作用,通过测定AC与不同浓度、不同组分的核苷、碱基混合体系的吸光度,证明了AC对尿嘧啶、尿苷具有分子识别作用,能从其它核苷或碱基共存的体系中将尿苷或尿嘧啶识别出来.; 张海燕史慧杰施宪法; 关键词：杯芳烃衍生物腺嘌呤分子识别紫外分光光度法

New Chiral Calixarene Derivatives: Syntheses and Their Chiral Recognition Toward Amino Acids by UV-Vis Spectroscopy: 2008年; Three novel types of chiral calixarene derivatives 5, 8, and 10 were designed and synthesized by introducing chiral units to parent calixarenes. Their chiralities were confirmed by rotational analysis. Chiral recognition properties of these host compounds towards L- and D-threonine were studied by UV-Vis spectroscopy. The results indicated that calixarene derivatives 5 and 8 exhibited good chiral recognition capabilities toward L- or D-threonine. Although calixarene derivative 10 had no evident chiral recognition ability, the supramolecules of calixarene derivative 10 with L- or D-threonine showed a hypochromic effect or hyperchromic effect respectively. Therefore, calixarene derivative 10 might serve as a good chiral UV-indicator.; GU Jin-yingHE Wan-pingSHI Xian-faJI Liang-nian; 关键词：光谱学

Flavonoids Inhibit Heparin-induced Aggregation of the Third Repeat（R3）of Microtubule-binding Domain of Alzheimer’s Tau Protein: ＜正＞The flavonoids comprise an important group of naturally occurring bioactive polyphenolics,ubiquitous in pla...; Han Lin-Jie; 文献传递

SDS-induced Alzheimer’s Tau Fragment R3 Fibrillization Possibly Follows a Micelle-facilitated Mechanism: ＜正＞One characteristic feature of brains afflicted with Alzheimer’s disease is the abnormal assembly of tau pro...; Leng-Feng Zheng,Dan-Jing Yang,Tian-Ming Yao,~* Liang-Nian Ji Department of Chemistry,Tongji University,Shanghai,200092,China; 文献传递

Interaction of Bio-macromolecules with metal ions and complexes: The incidence of Alzheimer’s discase incrcases dramatically with age,however, only a small percentage is direc...; 姚天明Shi ShuoYao Jun-LiangJi Liang-Nian

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国家自然科学基金(20472065)