利用溶剂提取法、正相和反相硅胶柱层析、Sephadex LH-20、RP-HPLC等色谱方法,从排风藤95%乙醇提取物中分离得到6个化合物.通过理化性质和1 H NMR、13 C NMR等光谱数据鉴定化合物的结构为β-谷甾醇(1),β-胡萝卜苷(2),N-反式-香豆酰酪胺(3),N-反式-对羟基苯乙基阿魏酰胺(4),N-反式阿魏酰基-3-甲氧基酪胺(5),N-trans-feruloylo-ctopamine(6).其中化合物2～6为首次从该植物中分离得到.
Compound 1, N-methyl-N-((2-(p-tolyl)quinolin-4-yl)methyl)aniline (C24H22N2), as a potential drug for the treatment of acid-related diseases has been synthesized via palladium-catalyzed intramolecular hydroarylation. The compound was characterized by MS and NMR spectra. Meanwhile, the crystal of 1 was obtained and determined by X-ray single-crystal diffraction. Crystal data: triclinic system, space group Pī, a = 5.548(5), b = 11.545(10), c = 14.546(12), α = 90.427(15), β = 90.727(14), γ = 101.099(16)°, V = 914.1(13)3, Z = 2, F(000) = 360, Dc = 1.230 g/cm3, μ = 0.072 mm-1, R = 0.0564 and wR = 0.1616 for 9768 independent reflections (Rint = 0.0447) and 3003 observed ones (I > 2σ(I)).
A pair of E/Z-isomers of 2-phenyl-6,7-dihydrobenzofuran-4(5H)-one O-cyanomethyl oxime,C16H14N2O2,as potential drugs for treating peptic ulcer and other acid-related diseases have been synthesized and characterized by IR,MS and NMR spectra.Meanwhile,the crystal of IIIa was obtained and determined by X-ray single-crystal diffraction.Crystal data: monoclinic system,space group P21 /c,a = 8.423(8),b = 19.596(16),c = 8.770(8),β = 107.750(12)°,V = 1379(2)3,Z = 4,F(000) = 560,Dc = 1.283 g/cm3,μ = 0.086 mm 1,R = 0.0681 and wR = 0.2029 for 14472 independent reflections(Rint = 0.0782) and 2428 observed ones(I > 2σ(I)).
通过溶剂提取法和多种色谱方法对宜昌润楠(Machilus ichangensis Rehd.et Wils.)的干燥茎枝进行分离纯化,利用现代波谱技术(MS、1 H NMR、13 C NMR、DEPT、CD)和理化性质进行结构鉴定.从宜昌润楠95%乙醇提取物中分离得到16个酚类化合物,分别鉴定为(2R,3R)-4′-羟基-5,7,3′-三甲氧基黄烷-3-醇(1),(2R,3R)-3-羟基-5,7-二甲氧基-4′,5′-亚甲二氧基黄烷(2),(+)-儿茶素(3),(-)-表儿茶素(4),柚皮素(5),达维荚蒾苷元(6),反式对香豆酸(7),咖啡酸(8),阿魏酸(9),异阿魏酸(10),东莨菪素(11),异东莨菪素(12),胡椒基酸(13),香草酸(14),原儿茶酸(15),丁香酸(16).所有化合物均为首次从该植物中分离得到.
