Enhanced stability of polyplexes in physiological condition was an important prerequisite for successful systemic gene delivery.Herein novel method was reported to develop stable gene vector by nanotechnology.Thiolated polyplexes were constructed and then cross-linked with gold nanoparticles(AuNPs)by gold-thiol interactions.TEM pictures showed that AuNPs were attached to the shell of spherical polyplexes.The hybrid gene vector was stable enough in physiological condition and maintained efficient transfec...
Gene delivery systems are one of key issues that limit the development of gene therapy. The novel non-viral gene delivery systems fabricated via supramolecular assem- bly have begun to show increasing promising and applica- tions in gene therapy due to its suitable nanometric size, controllable structure and excellent biocompatibility. In this review, the fundamental and recent progress of non-viral gene supramolecular assembly is reviewed. Artificial vi- ruses——the future direction of non-viral gene delivery sys- tems are also described.
