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国家自然科学基金(30770512)

作品数:9 被引量:9H指数:1
相关作者:陈畅黄波张栩周晞晞李江美更多>>
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发文基金:国家自然科学基金全球变化研究国家重大科学研究计划国家重点基础研究发展计划更多>>
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一氧化氮代谢调控在果蝇视觉学习记忆中的作用和机制
<正>自发现内皮舒张因子(endothelial derived relaxing factor,EDRF)就是一氧化氮(nitricoxide,NO)以来,NO一直都是生物学界的明星分子。NO作为神经信使分子,参与包括...
侯勤龙江火清刘力陈畅
关键词:FDH一氧化氮
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Quantitative proteomic analysis of S-nitrosated proteins in diabetic mouse liver with ICAT switch method被引量:1
2010年
In this study we developed a quantitative proteomic method named ICATswitch by introducing isotope-coded affinity tag(ICAT)reagents into the biotin-switch method,and used it to investigate S-nitrosation in the liver of normal control C57BL/6J mice and type 2 diabetic KK-Ay mice.We got fifty-eight S-nitrosated peptides with quantitative information in our research,among which thirty-seven had changed S-nitrosation levels in diabetic mouse liver.The S-nitrosated peptides belonged to fortyeight proteins(twenty-eight were new S-nitrosated proteins),some of which were new targets of S-nitrosation and known to be related with diabetes.S-nitrosation patterns were different between diabetic and normal mice.Gene ontology enrichment results suggested that S-nitrosated proteins are more abundant in amino acid metabolic processes.The network constructed for Snitrosated proteins by text-mining technology provided clues about the relationship between S-nitrosation and type 2 diabetes.Our work provides a new approach for quantifying S-nitrosated proteins and suggests that the integrative functions of S-nitrosation may take part in pathophysiological processes of type 2 diabetes.
Xu ZhangBo HuangXixi ZhouChang Chen
关键词:QUANTITATIVES-NITROSATION
S-nitrosylation/Denitrosylation and Apoptosis of Immune Cells被引量:7
2007年
Nitric oxide (NO) as an immunoregulatory molecule, predominantly depending on S-nitrosylation, acts as a versatile player that executes its regulation and signal transduction for exerting its multi-functions and pleiotropy. Apoptosis of immune cells is an intricate process coupled with positive/negative selection depending on integrated diverse endogenous and exogenous signals and functions to sustain homeostasis in the immune system. Here, the dual roles of NO depending on its concentration in apoptosis are reviewed, breeding up a switch mode in the apoptotic process. Following comments of different switches from apoptosis-death, a new finding of checkpoint (early fluorescence point) of GSNO-initiated thymocyte apoptosis and NOS-GSNOR double control are highlighted. Moreover, S-nitrosylation/denitrosylation, being as a redox switch, logically approaches to networks of metabolism itself and further accesses the neuroendicrine-immune-free radical network as a whole. Moreover, the host defense mediated by NO on pathogens, via protein S-nitrosylation are also discussed.
Shaojin DuanChang Chen
关键词:APOPTOSISSWITCH
一氧化氮通过对CRM1的亚硝基化修饰抑制经典的核输出
一氧化氮(Nitric Oxide,NO)作为一种重要的气体信号分子,对心血管系统、免疫系统和神经系统的功能调节和在信号转导中的作用已被广泛确认。其作用机制除了经典的
王鹏刘光慧吴凯源曲静黄波张栩Larry Gerace陈畅
关键词:一氧化氮
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Nitric oxide represses the classical nuclear export pathway by inhibiting interaction of CRM1 and Nuclear Export Sequences (NES)
<正>S-Nitrosylation plays important roles in regulation of protein function and signaling transduction. However...
Peng Wang
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PI4KⅡα通过调控HIF-1α影响肿瘤诱导的血管新生
2009年
背景:肌醇磷脂4位激酶(PI4K),作为PI信号通路中第一个起重要作用的激酶在肌醇磷脂循环过程中能催化肌醇磷脂(PI)
李江美陆宇张锦华秦志海陈畅
A novel crosstalk between S-nitrosation,ubiquitination,and sumoylation:NO regulates sumoylation through S-nitrosation-dependent degradation of Pias3
<正>Small ubiquitin-related protein modifiers (SUMO) modification is an important mechanism for posttranslation...
Jing Qu.
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特异检测蛋白质巯基亚硝基化的方法
<正>生物素转换方法(biotin switch assay),一种设计用来检测蛋白质巯基亚硝基化的方法,已经极大的推动了一氧化氮信号转导研究和蛋白质巯基亚硝基化的研究。但是我们
黄波陈畅
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二氧化硅纳米粒子对蛋白质聚集的影响
<正>纳米材料,尤其是纳米粒子,在生物医学领域的运用越来越广泛。但是纳米材料会对生物大分子(如蛋白质,脂,核酸)产生何种影响,目前还很不清楚。纳米材料对蛋
周晞晞刘岩柯莎陈畅
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一氧化氮通过对CRM1的亚硝基化修饰抑制经典的核输出
2009年
一氧化氮(NitricOxide,NO)作为一种重要的气体信号分子,对心血管系统、免疫系统和神经系统的功能调节和在信号转导中的作用已被广泛确认。
王鹏刘光慧吴凯源曲静黄波张栩Larry Gerace陈畅
关键词:一氧化氮
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