In this paper,we introduce our finding of the effects of C_(60) nanoparticles (NP) infiltration on mechanical properties of cell and its membrane.Atomic force microscopy (AFM) is used to perform indentation on both normal and C_(60) infiltrated red blood cells (RBC) to gain data of mechanical characteristics of the membrane.Our results show that the mechanical properties of human RBC membrane seem to be altered due to the presence of C_(60) NPs.The resistance and ultimate strength of the C_(60) infiltrated RBC membrane significantly decrease.We also explain the mechanism of how C_(60) NPs infiltration changes the mechanical properties of the cell membrane by predicting the structural change of the lipid bilayer caused by the C_(60) infiltration at molecular level and analyze the interactions among molecules in the lipid bilayer.The potential hazards and application of the change in mechanical characteristics of the RBCs membrane are also discussed.Nanotoxicity of C_(60) NPs may be significant for some biological cells.
We present a continuous-wave singly-resonant optical parametric oscillator with 1.5% output coupling of the resonant signal wave, based on an angle-polished Mg O-doped periodically poled lithium niobate(Mg O:PPLN), pumped by a commercial Nd:YVO4laser at 1064 nm. The output-coupled optical parametric oscillator delivers a maximum total output power of 4.19 W with 42.8% extraction efficiency, across a tuning range of 1717 nm in the near- and mid-infrared region.This indicates improvements of 1.87 W in output power, 19.1% in extraction efficiency and 213 nm in tuning range extension in comparison with the optical parametric oscillator with no output coupling, while at the expense of increasing the oscillation threshold by a factor of ～ 2. Moreover, it is confirmed that the finite output coupling also contributes to the reduction of the thermal effects in crystal.
