公共文化服务平台

共 2 条记录，以下是 1-2

全选清除导出

排序方式：

八角莲的化学成分研究被引量：27: 2011年; 目的研究八角莲Dysosma versipellis根茎的化学成分。方法运用硅胶、凝胶及RP-HPLC等多种色谱技术对八角莲根茎的化学成分进行分离纯化,并根据理化性质和波谱数据鉴定化合物的结构。结果从八角莲根茎95%乙醇提取物的醋酸乙酯和正丁醇萃取部位分离并鉴定了14个化合物,其中木脂素类化合物10个,分别为4′,5′-二去甲基鬼臼毒素(4′,5′-didemethylpodophyllotoxin,1)、鬼臼毒素(podophyllotoxin,2)、4′-去甲基鬼臼毒素(4′-demethylpodophyllotoxin,3)、山荷叶素(diphyllin,4)、鬼臼毒酮(podophyllotoxone,5)、苦鬼臼毒素葡萄糖苷(picropodophyllotoxin-4-O-β-D-glucoside,6)、4′-去甲基鬼臼毒素葡萄糖苷(4′-demethylpodophyllotoxin-4-O-β-D-glucoside,7)、山荷叶素葡萄糖苷(diphyllin-4-O-β-D-glucoside,8)、鬼臼毒素葡萄糖苷(podophyllotoxin-4-O-β-D-glucoside,9)、八角莲醇(dysosmarol,10);黄酮类化合物3个,分别为山柰酚(kaempferol,11)、槲皮素(quercetin,12)、山柰黄素-3-O-β-D-吡喃葡萄糖苷(kaempferol-3-O-β-D-glucoside,13);甾醇类化合物1个,为β-谷甾醇(β-sitosterol,14)。结论化合物1为新天然产物,化合物7和8为首次从该属植物中分离得到。; 姜飞田海妍张建龙叶青美江仁望; 关键词：八角莲鬼臼毒素木脂素黄酮类甾醇类

Absolute configuration of podophyllotoxone and its inhibitory activity against human prostate cancer cells被引量：4: 2015年; Podophyllotoxone(1) was isolated from the roots of Dysosma versipellis. The structure was determined by spectroscopic analysis in combination with single-crystal X-ray analysis. The absolute configuration of compound 1 was assigned based on the Flack parameter. It showed significant inhibitory activities against human prostate cancer cells PC3 and DU145 with IC50 values being 14.7 and 20.6 μmol·L-1, respectively. It also arrested the cells at G2/M phase. Tubulin polymerization assay showed that it inhibited the tubulin polymerization in a dose-dependent manner, and molecular docking analysis revealed a different binding mode with tubulin as compared with those known tubulin inhibitors.; LI JuanFENG JuanLUO ChengHerman Ho-Yung SungJIANG Ren-Wang; 关键词：传统医药药物发现生物制药生物系统

全选清除导出

共1页<1>

国家自然科学基金(21072078)