Label fusion is a powerful image segmentation strategy that is becoming increasingly popular in medical imaging. However, satisfying the requirements of higher accuracy and less running time is always a great challenge. In this paper we propose a novel patch-based segmentation method combining a local weighted voting strategy with Bayesian inference. Multiple atlases are registered to a target image by an advanced normalization tools(ANTs) algorithm. To obtain a segmentation of the target, labels of the atlas images are propagated to the target image. We first adopt intensity prior and label prior as two key metrics when implementing the local weighted voting scheme, and then compute the two priors at the patch level. Further, we analyze the label fusion procedure concerning the image background and take the image background as an isolated label when estimating the label prior. Finally, by taking the Dice score as a criterion to quantitatively assess the accuracy of segmentations, we compare the results with those of other methods, including joint fusion, majority voting, local weighted voting, majority voting based on patch, and the widely used Free Surfer whole-brain segmentation tool. It can be clearly seen that the proposed algorithm provides better results than the other methods. During the experiments, we make explorations about the influence of different parameters(including patch size, patch area, and the number of training subjects) on segmentation accuracy.
