The crystal structure of the title compound（E）-ethyl 2-（4-（2,4-dimethoxy benzylide-neamino）-5-（3,4,5-trimethoxyphenyl）-4H-1,2,4-triazol-3-ylthio）acetate（4,C24H28N4O7S,Mr = 516.17） was synthesized and determined by X-ray single-crystal diffraction.The crystal belongs to the monoclinic system,space group P21/n with a = 13.162（2）,b = 8.4506（13）,c = 22.602（4） ,β = 99.888（3）°,μ = 0.183 mm-1,V = 2476.5（7）3,Z = 4,Dc = 1.385 g/cm3,F（000） =1088,T = 110（2） K,R = 0.0426 and wR = 0.1216 for 3859 observed reflections with I 2σ（Ⅰ）.
