2,3-Dihydro-2-aryl-4(1H)-quinazolinones were prepared in good yields via condensation of o-aminobenzamide with aldehydes promoted by a catalytic amount of Sc(OTf)3 under mild conditions.
Catalyzed by ytterbium(III) triflate hydrate [Yb(OTf)3.xH20], the Michael addition and cyclocondensation of α,β-unsaturated ketones with active methylene compounds to afford the 1,4-adducts and benzo[b]pyran derivatives, respectively were studied.
A Yb(OTf)3-catalyzed approach for the synthesis of pyrroles under solvent-free conditions was achieved, which could afford the desired products with yields ranged from moderate to excellent.
Bing ZuoJiu Xi ChenMiao Chang LiuHua Yue WuWei Ke Su