水环境中药品及个人护理品(pharmaceuticals and personal care products,PPCPs)的潜在生态风险已引起广泛关注。细胞色素P450在水生毒理学研究领域发挥着重要作用。本研究介绍了水生生物的P450酶系,综合分析了PPCPs对水生生物P450的影响,探讨了其中几类典型药物的作用机制,并对该领域今后的研究方向进行了展望。
In order to study toxicological effects of perfluorononanoic acid(PFNA), perfluorooctane sulfonate(PFOS), and their mixtures(PFNA/PFOS) on Daphnia magna(D. magna), a suite of comprehensive toxicity tests were conducted, including a 48-h acute toxicity test, a 21-day chronic test, a feeding experiment, and a biomarker assay. D. magna were exposed to aqueous solutions of PFNA and PFOS(alone and in combination) at concentrations ranging from 0.008 to 5 mg/L. The survival, growth, and reproduction of D. magna were monitored over a 21-day life cycle. The biomarkers, including acetylcholinesterase(ACh E), superoxide dismutase(SOD), and catalase(CAT) activities, were determined after seven days of exposure. PFOS was more toxic than PFNA based on the results of the acute toxicity test. Perfluorinated compounds(PFCs) inhibited both growth and reproduction of D. magna during the testing period. The ingestion rates and the biomarkers,including ACh E, SOD, and CAT activities, were significantly inhibited by PFCs in most cases. Moreover, the combined effects related to the growth and reproduction showed the antagonistic effects of PFCs.
