目的观察益气化聚颗粒联合西药治疗代谢综合征微量白蛋白尿的临床疗效。方法将100例代谢综合征微量白蛋白尿症患者随机分为治疗组与对照组,每组50例。治疗组在常规西医治疗基础上加用益气化聚颗粒,对照组在常规西医治疗基础上加用安慰剂。两组疗程均为12周,观察微量白蛋白尿的转阴率,比较尿液相关指标(MA、UACR、24 h TP、尿转铁蛋白及尿β2微球蛋白)、形体体征指标(BMI、WHR、SBP、DBP及MAP)、血糖(FPG、2 h PPG、Hb A1c及HOMA-IR)及血脂(TC、TG、LDL、HDL)的变化情况。结果 1试验期间无脱落病例,100例受试者均完成试验研究。2治疗组、对照组转阴率分别为28.00%和10.00%;组间转阴率比较,差异有统计学意义(P<0.05)。3组间治疗后比较,MA、UACR、24 h TP及尿β2微球蛋白水平差异有统计学意义(P<0.05)。4组间治疗后比较,BMI、WHR、SBP及MAP水平差异有统计学意义(P<0.05)。5组间治疗后比较,FPG、2 h PPG、Hb A1c及HOMAIR水平差异有统计学意义(P<0.05)。6组间治疗后比较,TG水平差异有统计学意义(P<0.05)。结论益气化聚颗粒联合西药治疗代谢综合征微量白蛋白尿,可有效控制疾病的进展,提高胰岛素敏感性,减轻中心性肥胖程度。
BACKGROUND:Microalbuminuria(MAU) is a key component of metabolic syndrome(MetS) and is an early sign of diabetic nephropathy as well.Although routine Western medicine treatments are given to MetS patients to control high blood pressure,hyperglycemia and dyslipidemia,some patients still experience progressive renal lesions and it is necessary to modify and improve the treatment strategy for MetS patients. OBJECTIVE:To investigate the efficacy of Yiqi Huaju Qingli Herb Formula,a compound traditional Chinese herbal medicine,in MetS patients with MAU when it is combined with routine Western medicine treatment. DESIGN,SETTING,PARTICIPANTS AND INTERVENTIONS:Sixty patients with MetS were randomized into the Chinese herbal formula group(CHF,Yiqi Huaju Qingli formula treatment in combination with Western medicine) and control group(placebo in combination with Western medicine).All treatments were administered for 12 weeks. MAIN OUTCOME MEASURES:Urinary microalbumin(MA),urinary albumin-to-creatinine ratio (UACR),24-hour total urine protein(24-hTP),body mass index(BMI),waist circumference (WC),waist-to-hip ratio(WHR),fasting plasma glucose(FPG),2-hour postprandial plasma glucose(2-hPPG),glycosylated hemoglobin(HbA1c),homeostasis model assessment for insulin resistance(HOMA-IR),blood lipid profile and blood pressure were observed. RESULTS:Compared with the control group,CHF treatment significantly decreased BMI (P<0.05),WC(P<0.01) and WHR(P<0.01).Both groups had significant decreases in FPG, 2-hPPG,HbA1c,HOMA-IR,MA,and UACR,with CHF treatment showing better effects on these parameters compared with the control treatment(P<0.05).Both treatments significantly reduced the levels of total cholesterol,low-density lipoprotein cholesterol and triacylglycerol(TAG),and a greater reduction in TAG was observed with CHF treatment(P<0.05).The level of high-density lipoprotein cholesterol did not change in the control group after treatment(P>0.05),whereas it significantly increased with CHF treatment(P<0.01).Compared with before the treat
BACKGROUND:Patients with hypertension coupled with metabolic syndrome(MetS) are among the high risk population in cardiovascular and cerebrovascular diseases.To reduce the prevalence of cardiovascular and cerebrovascular diseases,it is essential to appropriately control blood pressure together with other cardiovascular risk factors. OBJECTIVE:The current study was designed to investigate the therapeutic effects on blood pressure,blood pressure variability and other cardiovascular risk factors by giving Yiqi Huaju Formula,a compound traditional Chinese herbal medicine,in addition to routine treatment to hypertensive patients coupled with MetS. DESIGN,SETTING,PARTICIPANTS AND INTERVENTIONS:A total of 43 patients with hypertension coupled with MetS were recruited into this study.The enrolled patients were randomly divided into the Chinese herbal formula group(anti-hypertensive drugs plus Yiqi Huaju Formula,CHF) and the control group(anti-hypertensive drugs plus placebo).The CHF group enrolled 22 patients while the control group received 21 cases.Treatments were given for 12 weeks in both groups. MAIN OUTCOME MEASURES:Parameters examined include 24-hour ambulatory blood pressure monitoring,body mass index,waist circumference,waist-to-hip ratio,homeostatic model assessment for insulin resistance(HOMA-IR),fasting glycosylated hemoglobin(HbA1c),fasting plasma glucose,2-hour postprandial plasma glucose(PPG),fasting plasma insulin,serum lipid,etc. RESULTS:Compared with the control group,the CHF group had significant improvement (PO.01) in anthropometric parameters,FPG,HOMA-IR,blood pressure amplitude,blood pressure variability and blood pressure load. CONCLUSION:This study showed that integrated traditional Chinese and Western medicine treatment can achieve better results in controlling blood pressure as well as other cardiovascular risk factors.The mechanism of controlling of blood pressure may be associated with the improvement of insulin sensitivity due to the Yiqi Huaju intervention. TRIAL REGISTRATION IDENTIFIER:ChiC
Yi ChenDe-yu FuYu ChenYan-ming HeXiao-dong FuYan-qiu XuYi LiuXiao-tao FengTeng ZhangWen-jian Wang
