Enantioseparation of aminoglutethimide was performed by high-speed counter-current chromatography with a two-phase system composed of ethyl acetate: methanol: water = 10: 1: 9. The lower phase contained 20 mmol/L of carboxymethly-β-cyclodextrin as chiral selector. The enantiomers were separated in 1.2 h and identified by chiral HPLC. This method was very efficient for the chiral preparative separation.
Ping AI Jia Chuan LIU Min ZI Zhi Hua DENG Zhi Hong YAN Li Ming YUAN
Single-walled carbon nanotubes(SWNTs)have a high adsorption ability and nanoscale interactions.Cellulose trisphenylcarbamates possess high enantioseparation ability in high-performance liquid chromatography(HPLC).Single-walled carbon nanotubes mixed with cellulose trisphenylcarbamate are coated on the silica gel as chiral stationary phases and higher enantioseparation factors are obtained.After a single-walled carbon nanotube is linked to the 6-position of cellulose 2,3-bisphenylcarbamate,its enantioseparation resolution increases compared to that of the cellulose trisphenylcarbamate.It is the first time that SWNTs have been applied to enantioseparation.The results indicate that the single-walled carbon nanotubes are good promoters of chiral recognition.This method can be used to improve the enantioseparation efficiency of the polysaccharide chiral stationary phases.
