Background： While depression and certain cardiac biomarkers are associated with acute myocardial infarction （AM1）, the relationship between them remains largely unexplored. We examined the association between depressive symptoms and biomarkers in patients with AMI. Methods： We performed a cross-sectional study using data from 103 patients with AM1 between March 2013 and September 2014. The levels of depression, N-terminal proB-type natriuretic peptide （NT-proBNP）, and troponin 1 （Tnl） were measured at baseline. The patients were divided into two groups： those with depressive symptolns and those without depressive symptoms according to Zung Self-rating Depression Scale （SDS） score. Baseline comparisons between two groups were made using Student＇s t-test for continuous variables, Chi-square or Fisher＇s exact test for categorical variables, and Wilcoxon test for variables in skewed distribution. Binomial logistic regression and multivariate linear regression were performed to assess the association between depressive symptoms and biomarkers while adjusting for demographic and clinical variables. Results： Patients with depressive symptoms had significantly higher NT-proBNP levels as compared to patients without depressive symptoms （ 1135.0 [131.5, 2474.0] vs. 384.0 [ 133.0, 990.0], Z = -2.470, P 0.013）. Depressive symptoms were associated with higher NT-proBNP levels （odds ratio [OR] 2.348, 95% CI： 1.344 to 4.103, P= 0.003） and higher body mass index （OR = 1.169, 95% confidence interval [CI]： 1.016 to 1.345, P = 0.029）. The total SDS score was associated with the NT-proBNP level （[3 ： 0.327, 95% CI：1.674 to 6.119, P = 0.001） after multivariable adjustment. In particular, NT-proBNP was associated with three of the depressive dimensions, including core depression （β = 0.299, 95% CI：0.551 to 2.428, P=0.002）, cognitive depression （β= 0.320, 95% CI：0.476 to 1.811, P=0.001）, and somatic depression （β= 0.333, 95% CI： 0.240 to 0.847, P = 0.001）. Neither
Yan RenJiao JiaJian SaLi-Xia QiuYue-Hua CuiYue-An ZhangHong YangGui-Fen Liu
