One new sesquiterpene lactone, corialactone E(1), one new neolignan, coriarianeolignan A(2), together with three known apocarotenoids(3-5) and one known neolignan(6) have been isolated from a CHCl_3 extract of the roots of Coriaria nepalensis. The structures including absolute configurations of 1-6 were elucidated through extensive NMR, HR-ESIMS, and CD data analysis. Structurally, compound 1 possessed novel variations in the structure, including the newly formed ether ring of C-3/0/C-9 and the lactone ring connecting C-13 and C-5. Compound 5 showed cytotoxic activity against SKOV3(human ovarian cancer)cells with IC_(50) values of 4.67 μmol/L. In vivo system, compound 3 showed anti-convulsant activity by 34%at the dose of 5 mg/kg.
One new sesquiterpene compound, namely, illihenlactone A(1), and one new prenylated C_6–C_3 compound, illihenryione H(2), along with three known sesquiterpenes(3–5) were isolated from the stems of Illicium henryi. The structures of 1 and 2 were elucidated by spectroscopic evidence including NMR, HRESIMS and circular dichroism(CD). Compound 2 exhibited a weak inhibitory ratio for bglucuronidase release induced by platelet-activating factor(PAF) in rat polymorphonuclear leukocytes(PMNs) in vitro.
