A series of acridine-1,2,3-triazole derivatives were designed, synthesized and characterized by NMR. 1-(2-methylacridinyl)-4-(4-methyl phenyl)-1,2,3-triazole(4f), C_(23)H_(18)N_4, was structurally determined by single-crystal X-ray diffraction. It crystallizes in the triclinic system, space group P1 with a = 9.585(4), b = 9.684(4), c = 11.339(5) ?, β = 88.250(7)o, V = 925.3(6), Z = 2, D_c = 1.258 g/cm^3, F(000) = 368, μ = 0.077 mm^(-1), the final R = 0.0808 and wR = 0.2218 for 3386 observed reflections(I > 2σ(I)). X-ray analysis indicates that the acridine ring is almost vertical to triazole ring with the dihedral angle nearly to be 75°. The crystal packing of the compound is stabilized mainly by π-π interaction. The preliminary biological tests display that some of the title compounds possess a good anti-tumour activity against MGC-803 and T24.
The new title compound N-(2-hydroxy ethyl) tetrahydropalmatine ammonium bromide has been synthesized starting from palmatine hydrochloride.The structure of the product was confirmed by 1H NMR,MS(ESI) and single-crystal X-ray diffraction.The title compound crystallizes in the triclinic system,space group P1 with a = 10.5887(11),b = 10.8652(9),c = 12.0914(12) ,β = 84.808(9)o,V = 1253.3(2) ?3,Z = 2,Dc = 1.355 g/cm3,F(000) = 530,μ = 1.680 mm-1,the final R = 0.0833 and w R = 0.2371 for 5112 observed reflections(I > 2?(I)).X-ray analysis indicates that the two planar parts(C(2) C(3) C(4) C(5) C(6) C(7) N(1) C(20) C(21) C(21)) and(C(7) C(8) C(9) C(10) C(12) C(14) N(15) C(16) C(17)) are not coplanar,with the dihedral angles to be 67.9°.Weak interactions mainly between O(5)–H(5)···O from two water molecules and O(5)···Br are observed.
HUO Li-NiCHEN RuiLIAO Yan-FangWEI Jan-HuaLI Pei-YuanHU Yue
