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Neuropeptide S reduced propofol- and ketamine-induced slow wave sleep through activation of its receptor in rats: Objective General anesthesia and natural sleep involve many obvious similarities.Some stimulatory neuropeptide...; Xiang-Pan KONGPeng ZHAOCan WANGJun-Fan XIEYu-Feng SHAOLi-Rong DAIJin LIChao-Yu DONGHai-Liang WANGYi-Ping HOU; 关键词：ANESTHETICS RATS; 文献传递

Neuropeptide S facilitates mice olfactory function through activation of cognate receptor-expressing neurons in the olfactory cortex: Objective Neuropeptide S(NPS) is a newly identified neuromodulator located in the brainstem and regulates vari...; Yu-Feng SHAOPeng ZHAOChao-Yu DONGJing LIXiang-Pan KONGCan WANGJun-Fan XIEHai-Liang WANGLi-Rong DAIYi-Ping HOU; 关键词：C-FOS; 文献传递

Effect of inhibition of GABA uptake in the tuberomamillary nucleus on sleep-waking states following the ventrolateral preoptic area lesion in rats: ＜正＞Objective Neurons containing gamma-aminobutyric acid（GABA） play an important role in the regulation from wa...; Min ZHANG,Kun FAN,Peng ZHAO,Yu-Feng SHAO,Xiang-Pan KONG,Qiong YAN,Yi-Ping HOU~* Department of Neuroscience,Anatomy,Histology and Embryology,Key Laboratory of Preclinical Study for New Drugs of Gansu Province,School of Basic Medical Sciences,Lanzhou University,Lanzhou 730000,China; 关键词：LESION; 文献传递

Neuropeptide S promotes active waking through activation of histaminergic and orexinergic neurons: ＜正＞Objective The effect of neuropeptide S（NPS） on characteristics and mechanisms in the regulation of sleep-wa...; Peng ZHAO,Yu-Feng SHAO,Min ZHANG,Kun FAN,Xiang-Pan KONG,Yi-Ping HOU~* Department of Neuroscience,Anatomy,Histology and Embryology,Key Laboratory of Preclinical Study for New Drugs of Gansu Province,School of Basic Medical Sciences,Lanzhou University,Lanzhou 730000,China; 关键词：IMMUNOHISTOCHEMISTRY HISTAMINE OREXIN; 文献传递

Estazolam逆转结节乳头体核组胺引发的觉醒被引量：1: 2008年; 目的观察增加γ-氨基丁酸(gamma-aminobutyricacid,GABA)受体与GABA亲和力的Estazolam对结节乳头体核(tuberomammillary nucleus,TMn)组胺(histamine,HA)产生觉醒的作用,探究GABA与TMn的HA对睡眠-觉醒周期的调节。方法♂SD大鼠随机分为对照组,生理盐水组,Estazolam组,HA组,以及HA+Estazolam(2.5mg)组,HA+Estazolam(5mg)组。颅骨和颈肌植入脑电图(EEG)和肌电图(EMG)电极,带芯的不锈钢导管植入TMn邻近区以备微量注射药物。术后恢复7d,各组分别记录24h的EEG和EMG,分析睡眠-觉醒周期中各时相的变化。结果:TMn内注射HA(1μg.kg-1)在24h中觉醒时间增加(P<0.01),慢波睡眠被抑制,但不影响异相睡眠(paradoxicalsleep,PS)。灌胃给予Estazolam(5mg.kg-1)产生以深度慢波睡眠(SWS2)增加(P<0.01)为主要特征的总睡眠时间增加。在HA引起的觉醒达高峰(2h)的时候分别灌胃给予Estazolam2.5mg.kg-1与5mg.kg-1,使觉醒转为睡眠,并呈剂量依赖性。结论TMn内HA能神经元促进和维持觉醒,作用于GABA神经元末梢的苯二氮类(benzodiazepine,BZD)1受体的Estazolam,通过增加SWS2而增加总睡眠时间,并逆转HA引起的觉醒状态。; 孙祎娜张欣谢鹏杨旭光侯一平; 关键词：睡眠-觉醒周期 ESTAZOLAM Γ-氨基丁酸能神经元

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国家自然科学基金(30670677)