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Nifedipine reduces iron accumulation and dopamine neuron degeneration in the iron-overloaded substantia nigra of rats: ＜正＞Objective To investigate whether nifedipine,a blocker of L-type calcium channels can prevent iron accumulat...; Ze-Gang MA,Jun-Xia XIE~* Department of Physiology,Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines:Physiology,Medical College of Qingdao University,Qingdao,266071; 关键词：NIFEDIPINE IRON; 文献传递

Nifedipine reduces iron overload-induced dopamine neuron degeneration by inhibition of iron accumulation in the substantia nigra of rats: ＜正＞The effects of nifedipine on iron overload-induced neurodegeneration in the substantia nigra（SN）-striatum s...; Ze-Gang MA,Hong JIANG,Jun-Xia XIE~* Department of Physiology,Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines:Physiology,Medical College of Qingdao University,Qingdao,266071; 关键词：NIFEDIPINE IRON; 文献传递

杨梅黄酮减弱MPP^+诱导的MES23.5细胞的细胞毒性(英文): 2011年; 目的:探讨杨梅黄酮对MPP+处理的MES23.5细胞的保护作用。方法:实验分为空白对照组,MPP+处理组,MPP+和杨梅黄酮共处理组,分别处理MES23.5细胞24h后,应用Hoechst 33258染色观察各组细胞细胞核形态的改变,应用RT-PCR技术观察Bcl-2和Bax mRNA表达的改变。结果:杨梅黄酮能明显抑制MPP+引起的MES23.5细胞核固缩,核碎裂等形态学的改变,杨梅黄酮还可以对抗MPP+处理造成的MES23.5细胞的Bcl-2/Bax比率的降低。结论:杨梅黄酮对MPP+处理的MES23.5细胞具有保护作用。; 张凯马泽刚王俊谢安木; 关键词：MPP^+凋亡 CELLS

Myricetin attenuates MPP+-induced cytotoxicity by anti-oxidation and c-JNK modulation in MES23.5 cells: Myricetin is a typical flavonoid existing in many fruits and vegetables,which has a variety of biological func...; Kai ZHANG,Ze-Gang MA,Yuan LI,Jun-Xia XIE~* Department of Physiology,Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines:Physiology,Medical College of Qingdao University,Qingdao,266071; 关键词：MYRICETIN ANTI-OXIDATION MPP+; 文献传递

Effects of ghrelin in substatia nigra on haloperidol-induced catalepsy in rats: ＜正＞Objective Ghrelin is a 28-amino acid peptide that regulates growth hormone secretion,food intake,and energy...; Ze-Gang MA,Jun-Xia XIE~* State Key Discipline:Physiology(in incubation),Department of Physiology,Qingdao University,Qingdao 266071, China; 关键词：GHRELIN; 文献传递

L-type calcium channels were involved in 6-OHDA-induced neurotoxicity on PC12 cells and rats: ＜正＞Evidence suggested that L-type Cav1.3 calcium channel may play a key role in the pathogenesis of dopamine n...; Rong WANG,Ze-Gang MA,Nan-Nan WANG,Jie SONG,Jun-Xia XIE~* Department of Physiology,Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines:Physiology,Medical College of Qingdao University,Qingdao,266071; 关键词：6-HYDROXYDOPAMINE; 文献传递

硝苯地平对急性铁负载大鼠黑质DA能神经元的作用被引量：2: 2011年; 目的探讨L型电压门控型Ca2+通道阻断剂硝苯地平对急性铁负载大鼠黑质多巴胺(DA)能神经元的作用。方法雄性Wistar大鼠随机分为对照组、急性铁负载组以及硝苯地平干预组。应用逆转录-聚合酶链反应、铁含量测定等技术,检测黑质酪氨酸羟化酶(TH)mRNA的表达水平及铁含量。结果急性铁负载组大鼠黑质TH mRNA的表达水平较对照组明显降低,铁含量较对照组明显增高,硝苯地平预处理可逆转上述改变(F=100.293、56.202,P<0.01)。结论硝苯地平对急性铁负载大鼠黑质DA能神经元具有保护作用。; 王荣马泽刚谢俊霞; 关键词：硝苯地平铁黑质多巴胺

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国家自然科学基金(30800353)