目的:为了对糖尿病患者丰富的临床检查信息进行有效管理,建立一个糖尿病信息管理与分析系统,可实现糖尿病患者实验室检查及量表测试的信息存储、查询及量表测试的数据分析。方法:运用SQL Server作为后台数据库完成数据的存储,以Visual Studio C++6.0作为开发语言,通过Active X数据对象媒介连接数据库,再运用SQL查询语句对相应字段进行精确查询,采用简单易行的添加消息映射实现对糖尿病量表数据的分析计算功能。结果:系统包括数据库管理、信息管理、信息查询及数据分析4大模块,可实现糖尿病患者检查数据的增添、删改及查询功能,并可实现量表测试的分析。结论:系统界面友好,易于操作,利用已完成的数据分析系统进行糖尿病患者信息的管理、查询及量表测试的分析,有助于糖尿病相关的临床、教学及科研工作。
Mood disorders/psychosis have been associated with dysfunctions in the default mode network(DMN).However,the relative contributions of DMN regions to state and trait disturbances in pediatric bipolar disorder(PBD)remain unclear.The aim of this study was to investigate the possible mechanisms of PBD through brain imaging and explore the influence of psychotic symptoms on functional alterations in PBD patients.Twenty-nine psychotic and 26 non-psychotic PBD patients,as well as 19 age-and sex-matched healthy controls underwent a restingstate functional MRI scan and the data were analyzed by independent component analysis.The DMN component from the fMRI data was extracted for each participant.Spearman's rank correlation analysis was performed between aberrant connectivity and clinical measurements.The results demonstrated that psychotic PBD was characterized by aberrant DMN connectivity in the anterior cingulate cortex/medial prefrontal cortex,bilateral caudate nucleus,bilateral angular gyri,and left middle temporal gyrus,while non-psychotic PBD was not,suggesting further impairment with the development of psychosis.In summary,we demonstrated unique impairment in DMN functional connectivity in the psychotic PBD group.These specific neuroanatomical abnormalities may shed light on the underlying pathophysiology and presentation of PBD.
Yuan ZhongChun WangWeijia GaoQian XiaoDali LuQing JiaoLinyan SuGuangming Lu
