Reported here is fabrication of optically active micelles with broad range of morphologies in water, such as spheres, cylinders, and vesicles, from self-assembly of poly（ethylene glycol） monomethyl ether-b-poly- （methacryloyl-L-leucine methyl ester） （MPEG-b-PMALM） copolymer, which was prepared via atom transfer radical polymerization （ATRP） from vinyl monomer bearing chiral amino acid moieties, N-methacryloyl L-leucine methyl ester （MALM）, using bromine （Br） end-capped poly（ethylene golycol） monomethylether （MPEG-Br） as macroinitiator in the presence of CuBr/Me6TREN as catalytic system.
Fa Bao Zhao Zhi Lei Liu Jian Ping Sun Liang Feng Ji Wen Hu
We report here an approach toward the synthesis of optically active polyacrylamide bearing amino acid moieties, poly[Nmethacryloyl L-leucine methyl ester] （PMALM）, with controlled average number molecular weight （Mn） and relatively narrow polydispersity index （PDI, Mw/Mn 〈 1.3） by atom transfer radical polymerization （ATRP） using initiating system methyl 2-bromopropionate/CuBr/tris（2-dimethylaminoethyl） amine. The optical properties of the resulting polymers were evaluated from specific optical rotation value and CD spectra.
Liang Feng Fa Bao Zhao Zhi Lei Liu Jian Ping Sun Ji Wen Hu
