Objective To observe the regulation of Fengxiaofang on the expression of gene Gob-5 in ovalbumin-challenged asthmatic mice.Methods The murine model of allergic asthma established by ovalbumin was used.The model mice were treated experimentally with Fengxiaofang and Dexamethasone as a positive control.The quantitive expression of gene Gob-5 in lung of mice was detected by real-time quantitative PCR.Results The expression of gene Gob-5 in lung of mice was down-regulated by Fengxiaofang.In the experiment,there were no significant differences between the one-fold or ten-fold dosage groups and the normal control group.Gene Gob-5 expression in five-fold dosage was significantly lower than that in the normal control group.Conclusion Fengxiaofang has the effect of lowering the expression of gene Gob-5 which maybe related to the potency on asthmatic disease.
BAI Gen-ben1,LIU Yang1,LI You-lin2,MA Xiao-xin1,YAN Shi2,FAN Chang-zheng2,GUO Ya-hong1 1.School of Chinese Materia Medica,Beijing University of Traditional Chinese Medicine,Beijing 100102,China 2.China-Japan Friendship Hospital,Beijing 100029,China
