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国家自然科学基金(Keyprogram)

作品数:4 被引量:2H指数:1
相关作者:董小平高晨张宝云王小凡李锋更多>>
相关机构:中国疾病预防控制中心首都儿科研究所更多>>
发文基金:国家自然科学基金广东省自然科学基金更多>>
相关领域:理学生物学农业科学机械工程更多>>

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恶性胃肠道间质瘤CT特点与临床病理分析比较:影像学表现与恶性潜能相关性分析(英文)
2011年
Objective: In this pictorial essay, we described the clinical, pathologic, and computed tomographic (CT) findings of malignant gastrointestinal stromal tumors (MGISTs) and attempt to establish the correlation between radiologic appearance and malignant potential. Methods: This retrospective analysis included 20 patients receiving treatment for MGIST between 2008 and 2010. The diagnosis was established by pathology and immunohistochemistry. All these patients underwent preoperative CT. Clinical presentation, pathology and CT images were analyzed. Helical CT images were reviewed for morphologic features such as tumor size, number and location, tumor margins, necrosis, degree of enhancement and metastasis. Results: Gastrointestinal bleeding, abdominal pain and discomfort, and without clinical symptom were common findings and were observed in 9 (45%), 6 (30%), and 5 (25%) of the 20 patients. 8 (40%) tumors were located in stomach, and 10 (50%), 1 (5%) and 1 (5%) were located in small intestine, mesentery and peritoneum, respectively. Male to female ratio was about 1:2. The size of MGIST ranged from 2.6 cm to 17.5 cm with a mean of 8.7 cm. All tumors density was inhomogeneous and heterogeneous enhancement. MGISTs with highly malignant located in small intestine were about 30% higher than stomach. The "satellite" tumours were found in 6 cases with high malignant risk. 7 cases were suffered from liver metastasis, and 4 cases went with seeding into the abdominal cavity, 1 cases went with lymph node metastasis. Histologically, 19 cases (95%) were of spindle cell type. Immunohistochemical stains demonstrated a strong positivity for both c-kit (CD117) and CD34s enhancement in 19 (95%). Conclusion: Clinical expression is varied in MGIST patients. Female might be predominance in MGIST. The GISTs located in small intestine would tend to be more aggressive. The satellite tumours, necrosis and cystic degeneration were strongly benefit for MGIST diagnosis. Furthermore, intestinal obstruction doesn't support the diagnosis. Lymph n
Zhifeng XuAizhen PanFang YongYingyu ChenBin LiQiang GaoRenhua Wu
关键词:病理特征胃肠道恶性间质
Quantum key recovery attack on SIMON32/64
2021年
The quantum security of lightweight block ciphers is receiving more and more attention.However,the existing quantum attacks on lightweight block ciphers only focused on the quantum exhaustive search,while the quantum attacks combined with classical cryptanalysis methods haven’t been well studied.In this paper,we study quantum key recovery attack on SIMON32/64 using Quantum Amplitude Amplification algorithm in Q1 model.At first,we reanalyze the quantum circuit complexity of quantum exhaustive search on SIMON32/64.We estimate the Clifford gates count more accurately and reduce the T gate count.Also,the T-depth and full depth is reduced due to our minor modifications.Then,using four differentials given by Biryukov in FSE 2014 as our distinguisher,we give our quantum key recovery attack on 19-round SIMON32/64.We treat the two phases of key recovery attack as two QAA instances separately,and the first QAA instance consists of four sub-QAA instances.Then,we design the quantum circuit of these two QAA instances and estimate their corresponding quantum circuit complexity.We conclude that the quantum circuit of our quantum key recovery attack is lower than quantum exhaustive search.Our work firstly studies the quantum dedicated attack on SIMON32/64.And this is the first work to study the complexity of quantum dedicated attacks from the perspective of quantum circuit complexity,which is a more fine-grained analysis of quantum dedicated attacks’complexity.
Hui LiuLi Yang
SINGLE LANTHANUM TRIS(N-PHENYLETHYL-3,5-DI-t-BUTYLSALICYLALDIMINATO)S INITIATOR FOR RING-OPENING POLYMERIZATION OF 1,4-DIOXAN-2-ONE IN BULK
2008年
A rare earth Schiff base complex:lanthanum tris(N-phenylethyl-3,5-di-t-butylsalicylaldiminato)s [La(OPEBS)_3] was successfully applied as single component initiator for the ring-opening polymerization of 1,4-dioxan-2-one (PDO) in bulk.The influence of reaction conditions,such as polymerization temperature,the molar ratio of the monomer to initiator (M/I) on the monomer conversion and molecular weight of the polymer has been investigated.Poly(1,4-dioxan-2-one) with a viscosity-average molecular weight (My...
郑豪沈之荃
PrP可抑制tau介导的体外微管形成作用被引量:2
2005年
目的研究朊蛋白(PRP)对微管相关蛋白(TAU)介导的体外微管形成的影响。方法我们从兔脑组织中纯化出微管蛋白,并纯化出原核表达的TAU和PRP蛋白。利用电子显微镜技术显示微管蛋白的聚集、TAU对微管蛋白的聚集的影响,及PRP对TAU介导的微管蛋白形成微管的影响。通过GST PULL DOWN实验研究TAU与微管蛋白的相互作用,PRP对TAU与微管蛋白相互作用的影响。结果电子显微镜负染显示纯化的微管蛋白在一定的实验条件下可聚集形成直径为25 NM的微管结构。在反应体系中加入TAU后微管样结构的形成明显增加,而加入PRP后可显著地抑制TAU对微管结构形成的促进作用。重组TAU能与提取的天然微管蛋白在体外结合,而PRP可明显地抑制TAU与微管蛋白的结合作用,并呈现剂量依赖关系。结论 TAU蛋白可促进微管蛋白形成微管结构,而PRP可通过与TAU的相互作用抑制微管的形成。
韩俊王小凡姚海兰高晨李锋张宝云姜慧英董小平
关键词:朊蛋白微管蛋白微管
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