Two new phenylpropanoid glycosides named cuneataside E(1) and cuneataside F(2), were isolated from the aerial parts of Lespedeza cuneata(Dum. Cours.) G. Don, whose structures were E and Z isomer, respectively. Their structures were elucidated on the basis of comprehensive spectroscopic analysis(UV, IR, HR-ESI-MS, 1D and 2D NMR). In in vitro bioassays at 10 μmol/L, compound 1showed moderate hepatoprotective activity against N-acetyl-p-aminophenol(APAP)-induced toxicity in He G2 cells.
