A 1:1 reaction of triphenyltin chloride with potassium N-[(3,5-dibromo-2-hydroxyl- phenyl)methylene]valinate in benzene led to the formation of a novel mixed organotin dinuclear complex, (HL)SnPh3Ph2SnL [L=2-O-3,5-Br2C6H3CH=NCH(i-Pr)COO], by means of a facile phenyl-tin bond cleavage process. In the complex, there are two distinct types of carboxylate moieties and a trans-O2SnC2N and a trans-O2SnC3 in distorted trigonal bipyramidal geometries were bridged by a carboxylate group. In vitro antitumor activity of the complex against three human tumour cell lines (HeLa, CoLo205 and MCF-7) was found to be much higher than cis-platin used in clinic.
Lai Jin TIANYu Xi SUNGuo Ming YANGBo Chu QIANZhi Cai SHANG
The title compounds, PhX2SnCH2CH2CO2Me (X = Cl, 1a; Br, 1b; I, 1c), readily underwent transesterification into the corresponding analogues, PhX2SnCH2CH2CO2R when reacted with an alcohol ROH. The structural features of these compounds were described, and the possible mechanism of the novel transesterification was suggested.
