In order to improve the performance of the attribute reduction algorithm to deal with the noisy and uncertain large data, a novel co-evolutionary cloud-based attribute ensemble multi-agent reduction(CCAEMR) algorithm is proposed.First, a co-evolutionary cloud framework is designed under the M apReduce mechanism to divide the entire population into different co-evolutionary subpopulations with a self-adaptive scale. Meanwhile, these subpopulations will share their rewards to accelerate attribute reduction implementation.Secondly, a multi-agent ensemble strategy of co-evolutionary elitist optimization is constructed to ensure that subpopulations can exploit any correlation and interdependency between interacting attribute subsets with reinforcing noise tolerance.Hence, these agents are kept within the stable elitist region to achieve the optimal profit. The experimental results show that the proposed CCAEMR algorithm has better efficiency and feasibility to solve large-scale and uncertain dataset problems with complex noise.