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张敏

作品数:5 被引量:30H指数:2
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凋亡基因bcl-2在胸腺增生性疾病中的表达
2002年
目的 :探讨bcl 2的表达与胸腺增生性疾病发生的关系。方法 :33例胸腺增生性疾病组织中 ,2 8例胸腺瘤按M H标准分类 ,并与Salyer标准作一比较。采用微波处理二步法进行bcl 2的免疫组化染色。 结果 :bcl 2主要在胸腺的上皮细胞成分中表达。髓质型胸腺瘤中bcl 2的阳性率高 ,其余胸腺瘤中阳性表达率则较低或阴性。在重症肌无力胸腺的髓质中bcl 2的表达远高于对照组胸腺。结论 :bcl 2在髓质型胸腺瘤上皮中的强表达可作为区分髓质型胸腺瘤和皮质型胸腺瘤的一个手段。过表达的bcl
张敏张容轩赵云兰陈志伟
关键词:凋亡基因BCL-2免疫组织化学基因表达胸腺瘤
针刺增效药在针刺镇痛复合麻醉肺切除中的作用被引量:2
2001年
Objective: To observe the effect of application of acupuncture analgesia enhancing synergists combined with acupuncture anesthesia to pulmonary lobectomy. Methods: Before anesthesia, intramuscular injection of tramadol(100 mg, a weak analgesic) and maxolon (20 mg, for enhancing acupuncture analgesia) and intravenous administration of holoperidol and fentany were given to the patients. 80 cases of patients were randomly divided into acupuncture combined with anesthetic (ACA) group (n=40) and general anesthesia (GA) group (n=40). Acupoints used were Houxi (SI 3), Zhigou (SJ 6), Neiguan (PC 6), Hegu (LI 4), Ximen (PC 4), Yuji (LU 10), Shugu (BL 65), Zulinqi (GB 41), Taichong(LR 3), Taixi (KI 3) and Taibai (SP 3). After insertion of the needles, every acupoint was stimulated by manipulating the needle for 1 min, 3 times altogether. Then intravenous drip of compound fluid of 1% procaine and scoline and endotracheal intubation were conducted. Before pulmonary lobectomy, procaine 0.25% (60 mL) was injected into the local subcutaneous tissues. During operation, the patient was kept basic consciousness. Results: In ACA group, the excellent rate and successful rate were 78% and 100% respectively. In comparison with GA group, the doses of the used anesthetics in ACA group (0.039±0.004 mL/kg/min) were decreased by 45%, being significantly lower than those of GA group (0.071±0.014 mL/kg/min) (P<0.001). Conclusion: Acupuncture combined with anesthetics for pulmonary lobectomy is effective and can lessen patients’ sufferings and thus is an applicable method in clinic.
童稳圃周红刘圣灵张敏
关键词:针刺麻醉肺切除镇痛复合麻醉
针刺镇痛应用于电视胸腔镜肺手术临床研究被引量:2
2001年
From February of 1997 to December of 2000, the acupuncture and drug anesthesia group applied manual acupuncture combined with intravenous administration of holoperidol and fentany to pulmonary operation under Vedio thoracoscope. 66 cases were randomly divided into acupuncture combined with intravenous injection of anesthetics (ACIIA) group (n=33) and general anesthesia (GA) group (n=33). Acupoints used were Houxi (SI 3), Zhigou (SJ 6), Neiguan (PC 6), Hegu (LI 4), Ximen (PC 4), Yuji (LU 10), Shugu (BL 65), Zulinqi (GB 41), Taichong(LR 3), Taixi (KI 3) and Sanyinjiao (SP 6) and were divided into 3 groups to be taken according to the incision location and the pulmonary operation. After insertion, each needle was manipulated continuously for 1 min, 3 times and 18 min altogether. Before anesthesia induction, intramuscular injection of tramadol (100 mg) and maxolon (20 mg) was given, followed by intravenous drip of compound fluid of 1% procaine and scoline. During operation, the acupuncture operator must follow the operation procedures, for example, when the pulmonary lobectomy was conducted and the incision extension needed, Neiguan (PC 6) and Taichong (LR 3) were stimulated with stronger manipulation. If necessary, fentany 0.1~0.2 mg was administered intravenously. Results showed that in ACIIA group, good anesthetic effect was found in 25 cases (78.8%) and the successful rate was 100%. In comparison with general anesthesia control group, the dose of dolantin compound liquid used was decreased by 43.5% per kilogram per minute.
周红童稳圃刘圣灵张敏
关键词:针刺麻醉镇痛肺部电视胸腔镜
单侧同肺叶内转移非小细胞肺癌的手术疗效及分期意义探讨
2002年
高文陈昶丁嘉安张敏张容轩
关键词:非小细胞肺癌外科手术疗效
临床酷似肺癌的肺隐球菌病12例临床病理分析被引量:26
2001年
目的 探讨肺隐球菌病 (PC)的病理、临床特点及术前误诊原因。方法 回顾性分析 12例PC的病理和临床资料。结果  12例PC多见于中年男性 ,首发症状常为咳嗽、痰血和发热 ,5例有慢性病史。X线胸片示病灶位于左肺 5例 ,右肺 7例 ;病灶直径≤ 3cm 2例 ,3— 5cm 3例 ,5— 7cm 5例 ,>7cm 2例 ;10例为单个块影或球形阴影 ,2例分别为多个类圆形结节影和斑片状影。胸部CT扫描 7例为密度不均的团块或结节影 ,4例考虑为肺癌 ,1例为感染灶 ,2例不能确定性质 ;ECT67Ga肺显像 5例 ,均为高度异常浓聚灶 ,提示肺癌 ;临床初诊和术前诊断多误诊为肺癌或肺肿瘤 ,无 1例初诊为PC。后经手术病理证实 10例 ,痰菌明确 2例。病理学检查 8例有隐球菌肉芽肿形成 ,2例分别为含菌的纤维结缔组织病灶和胶样病灶 ;肉眼标本质硬灰白无包膜。结论 PC的临床和影像学表现缺乏特征性 ,肉眼标本与肺癌不易区别 ,诊断有赖于病理组织学检查 ;
易祥华张容轩高文张敏马前立汪浩
关键词:肺隐球菌病临床病理学肺癌误诊
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