目的:系统全面探讨膏方辅助治疗慢性阻塞性肺疾病(COPD)的临床及其相关Meta分析。方法:检索国内外中英文数据库近五年关于膏方治疗COPD的随机试验(RCT),利用Revman 5.3软件开展偏倚风险评价和Meta分析。结果:共纳入22篇文献、研究对象1745例,包括治疗组876例,对照组869例,Meta分析结果表明:与单一西药疗法比较,膏方增强总有效率(TE) [OR = 3.64, 95% CI (2.36, 5.59), P Objective: To systematically and comprehensively investigate the clinical and related Meta-analyses of the adjuvant treatment of chronic obstructive pulmonary disease (COPD) with plaster formula. Methods: Randomized trials (RCTs) of plaster prescriptions for the treatment of COPD in the past five years were searched in Chinese and English databases at home and abroad, and risk of bias assessment and Meta-analysis were carried out using Revman 5.3 software. Result: A total of 22 articles and 1745 study subjects were included, including 876 cases in the treatment group and 869 cases in the control group, and the results of Meta-analysis showed that compared with a single Western drug therapy, the total effective rate (TE) was enhanced by the plaster formula [OR = 3.64, 95% CI (2.36, 5.59), P < 0.00001], increased the percentage of forced expiratory volume in 1 second to predicted value (FEV1%) [MD = 4.91, 95% CI (3.39, 6.43), P < 0.00001], reduced the number of acute exacerbations [MD = −0.34, 95% CI (−0.39, −0.28), P < 0.00001], and the adverse effects were mild and few. Conclusion: The addition of ointment in the treatment of COPD can significantly improve the overall physiological indexes of patients, including alleviating respiratory symptoms, and enhancing patients’ exercise ability and immunity, and has no obvious side effects, therefore, it is recommended to use ointment as an adjuvant drug for COPD, and ensure the safety and effectiveness of the drug through large-scale, high-precision, and multi-point monitoring experiments.
目的通过客观的指标和电镜下肾组织病理变化情况,探讨国医大师郭子光的复肾功方对慢性肾功能衰竭(chronic renal failure,CRF)大鼠肾组织的影响。方法 SD雌性大鼠50只,随机分为正常组、模型组、复肾功方高剂量组、复肾功方中剂量组、复肾功方低剂量组。正常组常规喂养,其余4组给予5%腺嘌呤饲料喂养制作CRF大鼠模型,持续喂养21 d。造模成功后,正常组和模型组予以生理盐水按每天20 m L/kg体质量的剂量灌胃,复肾功方组予以复肾功方高中低组分别按每天30、20、10 m L/kg的剂量进行治疗,连续喂养30 d。检测各组大鼠血肌酐(Scr)、血尿素氮(BUN)水平,在电镜下观察肾组织超微结构形态变化。结果与正常组相比,模型组血尿素氮,肌酐均增高(P<0.05),与模型组相比,复肾功方组血尿素氮,肌酐表达均降低(P<0.05);在电镜下,模型组均有不同程度肾损伤,复肾功方高中低组损伤相对模型组较轻。结论复肾功方可明显改善CRF大鼠模型肾脏功能,减轻肾损伤,抑制慢性肾衰竭的发生。
