In this paper, the influence of soil liquefaction on the vertical pressure of submarine pipeline was investigated under the wave loading through the wave flume test. The experiment was set with the same waves on the liquefied seabed and unliquefled seabed respectively, and the current pipeline vertical pressure was measured with the pressure transducers installed on the two opposite directions （i.e., straight up and straight down） at the same cross-section of the pipeline. The results showed that when the seabed was unliquefied, the two pressure curves varied periodically and overlapped completely, reaching the maximum and minimum at the same time respectively, and the resultant pressure fluctuated within a limited range. However, when the seabed was liquefied, the two pressure curves varied periodically, but they did not overlap completely. They did not reach the maximum （minimum） value at the same time either, and the resultant pressure fluctuated within a wider range. The experiment showed that the submarine stood higher resultant pressure in the vertical direction when the seabed was liquefied, which may cause the frequent sinking and fioatation of the pipeline, leading to its fatigue damage.
