目的:探讨甲状腺功能与2型糖尿病患者认知功能障碍的关系。方法:选取2023年4月至2023年08月山东大学第二医院健康查体中心收治的120例2型糖尿病患者作为研究组。根据2型糖尿病患者是否合并认知功能障碍分为非认知障碍组(n = 50)和认知障碍组(n = 70)。比较两组间一般资料、甲状腺功能及生化指标水平的差异;采用线性相关分析探讨甲状腺相关激素、生化指标水平及一般资料与认知功能的相关性;采用多因素Logistic回归分析探讨2型糖尿病患者认知功能障碍的影响因素。结果:在一般资料中,认知障碍组的收缩压及年龄更高、舒张压及受教育程度更低(P P P P Objective: To investigate the relationship between thyroid function and cognitive dysfunction in patients with type 2 diabetes mellitus. Methods: 120 cases of type 2 diabetic patients admitted to the author’s Health Screening Center from April 2023 to August 2023 were selected as the study group. The patients with type 2 diabetes mellitus were divided into a non-cognitive impairment group (n = 50) and a cognitive impairment group (n = 70) according to whether or not they had cognitive impairment. We compared the differences in general information, thyroid function and biochemical index levels between the two groups;A linear correlation analysis was used to explore the correlation between the levels of thyroid-related hormones, biochemical indicators, general information and cognitive functions. The influencing factors of cognitive dysfunction in type 2 diabetes mellitus patients were investigated by using univariate and multivariate logistic regression analysis;Results: In the general information, the systolic blood pressure and age were higher while the diastolic blood pressure and educational level were lower in the cognitive impairment group (P P P < 0.001). Multifactorial regression analysis showed that education level (OR = 0.752, 95%CI: 0.639~0.884), FT3 (OR = 0.24, 95%CI: 0.081~0.712), and
衰老相关认知功能障碍发病率随着社会老龄化而逐年升高,严重影响老年人群的生活质量,已经成为全球关注的热点问题。本研究就衰老相关认知功能障碍的定义、诊断和评估、发病机制、预防和治疗手段进行归纳总结,以期为衰老相关认知功能障碍的早期发现、早期诊断、早期治疗提供理论基础。The incidence of aging-related cognitive dysfunction increases year by year with the aging of society, which seriously affects the quality of life of the elderly population and has become a hot issue of global concern. This study summarises the definition, diagnosis and assessment, pathogenesis, prevention and treatment of aging-related cognitive dysfunction, with a view to providing a theoretical basis for early detection, early diagnosis and early treatment of aging-related cognitive dysfunction.
