The viscosity of polyethylene glycol-chitosan-H2O system at different compositions and its relevant systems were measured, and the intrinsic viscosity and Huggins parameters wereobtained. The interaction parameter, kAB, was determined from Huggins parameters by simple summation, and another interaction parameter α, was calculated by non-summation technique.It is found that the parameters, kAB and α, change with the compositions in a slmilar style. The results show that the kAB value, as the same as the α value, can be used to predict the compati-bility of polymers to each other.