To study dose - response and time - response relationship of different dosage mannitol prevent animal from drug myocardiurn ischemia. Methods After narcotism, the injection of lnannitol was performed on rats and rabbits ( 100 - 200 - 400 - 800rag·kg^-1 iv) and the injection of 0.9% sodium chloride on control group (lml#kg^-1 iv).Results The group injected with mannitol (100mg·kg^-1 iv) opposed to the myocardium ischemia rats and rabbits. But the groups injected with mannitol(400 - 800mg· kg^-1 ) inducted the myocardium ischemia. Coonclusionnitol reversalThe low concentration and milevel and large do saye of mannitol reversal.
Objective To observe the scopolamine on the lull ation of pentobarbital sodium of mice. Methods Took three groups in mice, then the group of chloramphenicol (25mg·kg^-1), the group of scopolamine (0.06mg·kg^-1), and the group of 0.9 % sodium chloride, injected the equal capacity of drug for leave each other. After 30 minutes, the injection of pentobarbital sodium (40mg·kg^-1) was performed on mice, to observe the time of lull preserve on mice. Results The group injected with chloramphenicol (25mg·kg^-1) have extended the time of the lull preserve of mice compared with 0.9 % sodium chloride, it has an absolute distance. The group of injected with scopolamine (0.06mg·kg^-1) have strong ation of increased the time of lull preserve on mice compared with 0.9 % sodium chloride. It has absolute distance. Conclusions The scopolamine has inhibitory effect on the activity of hepatic microsomal enzyme, it has increase the time of lull preserve.
To study the injection of Aasperal of Hubei produced, to struggle agaisnst inflammation of dose-response relationship. Methods Constantly poured kinds consistency of Aasperal down the stomach on the mice and rats. (per 100ml tach contain 2.5g,5g, 10g,20g,40g) twice a day,three consecutive days, At the three day, After poured stomach an hour. To use each grow of swelling feet rat and swelling tars of mice. To observe and take notes of kinds eonsiteney Aasperal of struggle against inflammation. Results Aasperal of Hubei produced existing to rely on dose-response relationship.
