An efficient method for the synthesis of 3hydroxyimino1,5 cyclooctdiamine dihydrochloride 6 was reported.From the starting material N,N’ditosyl3hydroxyl1,5dicyclooctdiamine 11,the title compound 6 was synthesized by five steps in high yield under mild reaction conditions.
The title compound N,N′ ditosyl 3 methoxyimino 1,5 diaza cyclooctane(4) has been prepared by two methods,the reactions of all steps are carried out under very moderate conditions and the overall yield is high.The structures of the new compounds 2,3,4 are characterized by elemental analysis,IR, 1H NMR and MS spectroscopy.
The new ligand（1R, 2R）（+）N,N-bis（8-quinolinesulfonylamino）-1,2-diphenylethylene diamine（BQSDA） was synthesized. The 1∶1 chiral crystal was formed from BQSDA with acetone. The crystal belongs to monoclinic, space group P21, a=0.971 7（2） nm, b=0.949 5（10） nm, c=1. 754 2（3） nm, α=γ=90°, β=97.130°, V=1.606（5） nm3, Dc=1.35 g/cm3. There is a hydrogen bond N1—H…O5 between BQSDA and acetone. The ligand has been used as the chiral catalyst in asymmetric hydrogen transfer reaction of acetophenone in a high yield with e. e. up to 66.5%.
