The selective bromination of paeonol (4-methoxy-2-hydroxyacetophenone) has been studied as function of solvents(methanol, ethanol, chloroform-ethyl acetate), reaction time, temperature and the mole ratio of reagents. The higher yield was obtained in polar solvents than in non-polar ones. The best solvent appeared methanol, and the mixtures of polar solvents were better than any single of them, except methanol. Paeonol and cupric bromide in mole ratio of 1∶2 in methanol under reflux temperature for five hours gave a bromination product in yield of 63.3%.
