Amino acid benzyl ester p-toluenesulfonic acids were synthesized under microwave irradiation condition by reaction of four amino acids with benzyl alcohol and p-toluenesulfonic acid,and then reacted with the N-phthaloyl-L-glutamic anhydride to yield compound 3a-d,hydrogenised and treated with NH3(g) to obtain the target compounds—thalidomide ammonium salt derivatives.The microwave-assisted method was used to synthesis the thalidomide amino acid benzyl ester p-tolunensulfonic acid,the reaction time was brought down with improved yield as compared with conventional heating method.The structures were comfirmed by MS,1H-NMR and elemental analysis.
