目的：探讨抗真菌治疗药物对重度慢性阻塞性肺疾病（COPD）患者的预防性治疗效果。方法：采用随机数字表法将本院的140例COPD患者分为两组，对照组予常规治疗，治疗组予常规治疗基础上加用氟康唑治疗，对比两组不同年龄层、不同临床分级患者住院期间肺部真菌感染率以及不良反应。结果：70~80年龄段患者中，治疗组和对照组真菌感染率分别是0（0/40）和15.00%（6/40），两组比较差异有统计学意义（P〈0.05）。在极重度COPD级别中，治疗组和对照组真菌感染率分别是0（0/36）和15.38%（6/39），两组比较差异有统计学意义（P〈0.05）。60~70年龄段患者中两组真菌感染率比较（0 vs 2.50%）及重度级别COPD中两组真菌感染率比较（0 vs 2.44%），差异均无统计学意义（P〉0.05）。两组间不良反应发生率无明显差异。结论：早期应用抗真菌药治疗对70~80年龄段或极重度COPD患者的肺部真菌感染有预防作用，且无明显不良反应。
To investigate the therapeutic effect and treatment rnachanism of hyperbaric oxygen (HBO) for Encephalon Trama Syndrome. Methods The retrospectively analysis were accessed by the effect of criteria after treatment. The research object was 180 patients who was divided into the group A with 90 patients with the rule treatment and the group B with 90 patients with the rule and HBO treatment, and statistical was made for those patients according to the standard of the effect of treamaent after the period of treatment was completed respectively. Results The effective ratio of group A was 53.89%,The effective ratio of group B after two to six HBO treatment was 94.45%, increased 40.56% Total effecitive ratio was 89.5%, the differences reached very significant (P <0.01). Conclusions The result indicated that the effects on after HBO are apparent. The treatment machanism is that HBO can increase the cereberal oxygenation, recover the cereberal aembioxidation, improve the cerebral anoxia; increase to form the side-branch nrculation, inrease to soften the scar tissue, improve the sympton.
