细胞中微核的出现能反映出染色体畸变的情况,微核率与染色体畸变率之间的相关性显著,因而已将微核率作为测定细胞损伤程度的一种敏感指标。本文运用小鼠骨髓细胞微核试验方法对新型抗炎药尼美舒利进行遗传毒理学测试。以37.5,70,150,300 mg/kg 体重剂量作一次性用药剂量,以37.5 mg/kg 体重剂量间隔24 h 分3 d 连续用药。结果显示,不同剂量及不同给药时间所致微核率为1.9‰～2.3‰,与阴性对照组的差异无显著性(P>0.05)。由此表明,尼美舒利在动物体内无明显致突变性。
Objective:To explore the plasma catecholamines (CAs) concentration of postnatal depression and to analyze the relationships between postnatal depression and CAs level. Methods:Using high performance liquid chromatography (HPLC) to measure the subjects’ plasma noradrenaline (NE)?adrenaline (E) and dopamine (DA) concentration. The postnatal depression group was compared with depression, ante partum and normal group.Results: NE level of plasma in the depression group and the postnatal depression group were all higher than those of normal group P <0.05).E:there were no significant differences on E level of plasma between two groups. DA level of plasma in the postnatal depression group higher than that of normal group( P <0.01) but depression group and normal group had no significant difference ( P >0.05) .Conclusion:the plasma NE increase is relative to postnatal depression episode,the plasma DA may be relative to postnatal depression episode. The relationship between plasma and postnatal depression remains unclear.
