Objective To observe the scopolamine on the lull ation of pentobarbital sodium of mice. Methods Took three groups in mice, then the group of chloramphenicol (25mg·kg^-1), the group of scopolamine (0.06mg·kg^-1), and the group of 0.9 % sodium chloride, injected the equal capacity of drug for leave each other. After 30 minutes, the injection of pentobarbital sodium (40mg·kg^-1) was performed on mice, to observe the time of lull preserve on mice. Results The group injected with chloramphenicol (25mg·kg^-1) have extended the time of the lull preserve of mice compared with 0.9 % sodium chloride, it has an absolute distance. The group of injected with scopolamine (0.06mg·kg^-1) have strong ation of increased the time of lull preserve on mice compared with 0.9 % sodium chloride. It has absolute distance. Conclusions The scopolamine has inhibitory effect on the activity of hepatic microsomal enzyme, it has increase the time of lull preserve.
