Objective To study the effect of fluvastatin on changes of serum C-reactive protein(CRP) and soluable intercellular adhesion molecule-1(sICAM-1),soluabe vas-cular cell adhesion molecule-1(sVCAM-1) contents in patients with acute coronary syndrome(ACS). Methods 109 patients with ACS were randomly divided into fluvastatin-treated group(55 cases) and conventional therapy group (54 cases). The contents of serum CRP (with immunoturbidity method), sICAM-1,sVCAM-1 (with ELISA) were measured both before and after treatment for 8 weeks with fluvastat in in these cardiac patients as well as in 50 controls. Results ① Befor treatment, the levels of serum CRP, sICAM-1, sVCAM-1 were significantly higher in the patients with ACS than controls(P<0.01). ②After treatment,the levels of serum CRP, sICAM-1,sVCAM-1 in patients with fluvastatin decreased significantly(P<0.01), but the levels were not much changed in the conventional therapy group. Conclusion Fluvastatin can decrease inflammation and cell adhesion in patients with ACS .
